Managing Public and Private Organizations Research Paper

Managing Public and Private Organizations - Research Paper Example Most importantly, effective leadership significantly reduces power distances across people by building constructive relationship based on mutual respect and cross-cultural understanding. This motivates the workforce to work on common goals with greater sense of responsibility and accountability. Q2. Discuss the factors that influence individual behavior. (Chap 11) The major factors that influence individual behaviour are personal value system, cultural paradigms, self-efficacy and hierarchy of needs. Personal value system is important issue that serves as guideline for individual behaviour. The ethical considerations and moral code of actions influence and guide one’s actions and general behaviour. In the era of rapid globalization, diversity has become a key issue and cultural paradigms have emerged as pertinent factors that not only give distinct identity to individuals but also provide them with unique cultural identities. Hierarchy of needs vis-a-vis physiological, social security, self-esteem and self-actualization, of individuals motivates them to change their behaviour and work towards achievement of their desired goals. Q3. Discuss how behavior management can be utilized to motivate employees. (Chap 11) Behaviour management is crucial psychological tool used within management funda that helps to streamline and encourage right attitude and behaviour across employees in an organization. Behaviour management relies on the code of conduct and in creating a facilitating environment of motivation and re-enforcement with regard to the various needs and requirements of the employees (Dessler, 2007). Thus, merit based performance, incentives, reward and punishment etc. become key ingredients of behaviour management within an organization. SMART goals comprising specific, measurable, attainable, relevant and timely, are set by individuals to achieve their short term and long term personal and professional goals. Q4. Describe the communication process and h ow barriers to communication can be overcome.  Ã‚  (Chap 12) Effective communication facilitates in developing mutual respect and cross-cultural understanding that helps to resolve workplace conflicts and promote efficient, goal based teamwork to achieve organizational goals and objectives (Bateman & Snell, 2009). The major barrier to communication is the lack of cross-cultural values and psychological barriers like low self- esteem of people who may belong to diverse culture, race, colour and ethnicity. Understanding of cross-cultural values helps build strong relationship based on trust and mutual respect. Thus, overcoming the barriers of communication has emerged as powerful tool to develop cohesive work environment that motivates workforce to work for common goals collectively. Q5. Discuss how technology can be utilized to improve an organization’s informal communication.  Ã‚  (Chap 12) Technology has significantly redefined communication (Reynolds, 2010). The compute r, internet and other technological gizmos like smart phones have become important facilitators of communication. Through the use of electronic boards, email, video-conferencing etc. organizations promote informal communication across the workers. The electronic boards have become popular platforms for sharing information and solving queries. Encouraging workers for

The Impact of Employee Participation for Transparency Research Paper

The Impact of Employee Participation for Transparency - Research Paper Example The selection process needs to be ethical, legal, documented, transparent and should involve the current or existing employees of the firm (Larson & Gray, 2006). The participatory approach is also crucial towards the implementation of team working activities. According to renowned scholars, whenever a company is thinking of bringing a new employee in the organization, their potential collaboration with the coworkers and fit in the system is important. As a result of that when an employee itself is a part of the recruitment process they become more committed to making the new joining employee get accustomed to the situation and succeed in their professional life. Hence, it is evident that employee participation in the process of employee recruitment is a beneficial factor for the firm (Love & Bullen, 2009). This research paper will, however, concentrate on the hiring and recruitment process of the public agencies and to what extent participation of the employees would ensure transpare ncy in the recruitment process. Summary of the literature Selecting and retaining the valuable and efficient employees is a key to business success. Employees who seek continuous skill development, as well as add value to the organization, are the most vital resources of the organization. Thus, it is extremely important to value the employees as well as put more efforts in selecting the right candidates. The principal element of any recruitment plan is to enhance the quality of staffing and developing the overall productivity of the organization. ... g employees and hiring the new employees is an area of business where the company is expected to maintain high levels of transparency, lucidity, and responsibility. Although, the same is evident in many companies whereas some companies often fail in maintain transparency in the recruitment process and are alleged of getting involved in biases or deceptive activities. According to Mumford (2011), one of the most useful ways to maintain transparency in the recruitment process is to involve the existing employees in the recruitment process. The same concept is applicable to the public agencies as well. Since the principal aim of these organizations is to make the welfare of the general public and profit making intention are on the second list, high levels of honesty and veracity in the recruitment process are expected from them. A number of research studies have shown that the recruitment process of the organizations differs in various aspects. For example, some companies have lengthy s creening process whereas some have a unique evaluation system. Nevertheless, what is important is to maintain a greater level of lucidity.  

Decision Analysis for Management Judgment Essay Example | Topics and Well Written Essays - 750 words

Decision Analysis for Management Judgment - Essay Example Heuristics are simple and efficient rules which are using by the managers of an organization when they will go to take any important decision or making any judgment. There are three types of Heuristics and those are Availability Heuristic, Representative Heuristic, and Base-Rate Heuristic. Availability Heuristic helps to bring some plan or judgment in mind very easily and make a decision in a simple way. Representative Heuristic helps in a comparison between information and mental prototypes. Base-Rate Heuristic is a mental shortcut which helps to make decisions by using probability (Gilovich, Griffin, and Kahneman, 2002, pp. 549-554). Notion of SMARTA comprehensive plan should be made by the manager to do work and implement a plan in a smart way. Hard work is required but in the present market scenario, smart work is more needed than the hard work. Otherwise, there will be no value only for hard work. Then also a growth of the organization will be improved in a smart way. The smart method also can be used to set management objectives. Here ‘S’ means specific, ‘M’ for measurable, ‘A’ for achievable, ‘R’ means realistic and ‘T’ indicates time-based which is very much essential to set the proper objectives of a business.Simulation can be explained as a form of science. This scientific tool can be used in experimental purpose without exposure to risk. Some real world factors and some good underlying assumptions help to do this experiment.

Case Study on Chilli Processing Plant Essay Example for Free

Case Study on Chilli Processing Plant Essay In Nimad area there is a place Bedia which comes in Khargaun district, there is an SHG which runs by the Mr. Jain. They runs a chilly processing plant where they purchase the red dry chilly from market and sometimes direct from farmer and produce red chilly powder. They sell this powder to Vindhya Valley Company (semi government body) and sometimes in local markets. When we talked to Mr. jain about the processing plant that we have some SHG groups of horticulture, where we includes chilly crop in our project and wanted to set up a chilly processing plant, Then he told us about to the all the parameters of chilly processing plants. Main requirements: (1) Pulverizer machine: This is the main machine of plant which is use for crushing of red dry chilly. Basically this machine is a combination of two different size and shape of pulverizer, where at first in first pulverizer we put down our raw material (red dry chilly) then it breaks into small pieces and these small pieces automatically goes into second pulverizer where second pulverizer crush that small pieces into powder. (2) Filter machine: This machine is basically used for raw material, where atfirst we put raw material on machine then it separates the unwanted particles of raw materials. (3) Mixer machine: It is basically used for mixing the oil in raw material, here we generally use food oil for mixing. Where we put down the fix quantity of oil and raw material in machine and it will mix automatically both items correctly. (4) Infrastructure: We needs at least 500 sq/meter of single hall for this whole set up where we can establish these all three machines at ideal difference. (5) Manpower: For this plant we needs at least 10 to 12 man who can operate the machines. (6) Electricity connection: Since pulverizer machine has two deferent’s power motor one motor of 12.50 horse powers and second motor of 15 horse powers. And also filter and mixing machine has individual motor. Here this is the pictures of cone pulverizer and macro pulverizer. Main cost parameters: At first we talk about the machinery cost where main machine pulverizer’s cost would be 225,000/-rs for (400kg / per day capacity), and the whole machinery set up would be around 5 to 6 lacks rupees and also sometimes it will be vary from company to company. Electricity bill would be around 8 to 10 thousand rupees. Manpower cost would be 36000/- to 43200/- rupees on monthly basis, where we will give their 120/-rs at daily basis. Manpower cost can vary from no. of working days or if we appoint man at monthly basis. Raw material or input parameters: As we know that pulverizer machine has 400kg / per day capacity,so we have to plan for sufficient raw material on capacity basis. Generally we purchases raw materials from local markets or mandi, but it will be costly comparably purchasing of direct farmer because farmer at first sell his chilly in local market or mandi then we purchases from there so here they will give this material in high rates to us because they added their cost on this material. So it would be better for us if we direct purchase from farmers. Since raw material cost will direct affect our production cost, so we have to focus on our backward linkages. Sometimes because of lack of raw material plant can be in shut down condition while on other side we are paying regularly our expenses like electricity bill, labor payment etc. If we talk about the payment mechanism at this stage it can be either cash basis or credit basis. Where if we are purchasing direct from farmers generally we have to pay him at a time or after some days, while if we are purchasing from markets or mandi. Then payment period extension can be possible for days or months. Final product marketing or output parameters: This is the important part of processing plant which will be directly affect our profit factor. Here at first we should have plan to direct marketing because it will ensure us that this particular quantity of our final product will have to sell, according to that we can decrease our risk factor otherwise we can’t depend on retail market. Here other important factor is transporting cost. It also affects our selling price, so we should have already plan to our direct marketing on distance basis. Sometimes big company wants more products in that condition it would be negotiable. Sometimes company does agreements of final product purchasing where agreements can be on quantity basis or timely basis (like different quantity on different month), so it will be also profitable for us that for particular period we are ensure that this much our final product will sell, according to that we can manage our production cost. There are two different options for final product marketing. (1) First one is that if you have good relation in local markets and ensure about personal sufficient selling of final product through local market or dealers, which can be a good deal for you here you can manage your selling price in terms of transportation cost. (2) Second one is that if you have good agreements from big company on quantity basis or timely basis at suitable price, then here you can compromise with your transportation cost because here also you are ensure that this much our final product will definitely sell at good price. Here this is the picture of red chilly processing plant. Reference: -Vardhaman SHG group Place– Bedia, dist. Khargaun (Nimad area)

Origins of Tissues Macrophages

Origins of Tissues Macrophages Ryan Lewis    Discuss current ideas about the origins of tissue macrophages and whether these origins influence the subsequent functions of macrophage Graphical Abstract Figure Legend: This figure highlights possible tissue macrophage origins and their development pathways. The essay discusses contradicting findings in the literature, involving three different publications; Sheng et al, 2015 (blue pathway), Hoeffel et al, 2015 (red pathway) and Perdiguero et al, 2015 (green pathway) which are shown in the figure. Cell positions relate to the time point they are established during embryonic development. Positions of yolk sac and foetal liver are also related to the times they are developed. Introduction In the late 19th century Ilya Metchnikoff discovered macrophages (Tauber, 2003) and since then our understanding of the immune system and its complexity has progressed to a stage where the macrophage is no longer as simple as was originally depicted by Metchnikoff. Although much more is known about tissue specific macrophages and their functions, the origins of these macrophages are less well understood including how their origins relate to the functions they have within specific tissues. This essay aims to address the current ideas about the origins of tissue macrophages and whether these origins influence the subsequent functions of macrophages. Macrophage Discovery and History As previously mentioned Metchnikoff discovered the macrophage late in the 19th century (Tauber, 2003). Metchnikoff published a paper talking about phagocytic cells he had observed in frogs, he described the phagocytic cells as being involved in host defence but also the clearing of dead and dying cells (Gordon, 2007). Mechnikoff then discovered the presence macrophages in starfish, which dont have a vascular system, which led him to the discovery of tissue-resident macrophages (Gordon, 2007). Metchnikoff received the Nobel prize for his studies on cellular immunity to infection in vertebrates which he shared with Paul Ehrlich who discovered humoral immunity (Gordon, 2007). It took roughly 80 years after Metchnikoffs discovery before the origin of the tissue macrophage was uncovered. It was proposed that tissue macrophages originated from circulating monocytes in the blood (van Furth and Cohn, 1968), this theory has persisted for the last 40 years however from recent studies we know t hat this is not the primary origin of the tissue macrophage. Shortly after the theory that tissue macrophages originated from circulating monocytes was proposed, it was discovered that tissue macrophages and monocytes are heterogenous and their heterogeneity is conserved in humans and mice (Gordon and Taylor, 2005). The discovery of monocyte subsets followed shortly after in 1983, which supported the theory that tissue macrophages originated from circulating monocytes (Yona and Jung, 2009). The theory that tissue macrophages are derived from circulating monocytes has been the prevailing view until very recently partly due to the arrival of advanced techniques including; fate mapping and ionizing radiation. In the last 5-6 years, many definitive publications have redefined our understanding of the origins of tissue macrophages (Epelman et al, 2014). Recent studies have shown that many tissue macrophages are established during embryonic development and continually self-replenish into adulthood independently of any input from circulating monocytes in the blood (Epelman et al, 2014; Ginhoux et al, 2010; Hashimoto et al, 2013; Yona et al, 2013). Tissue Macrophage Heterogeneity and Function Tissue macrophage have a huge degree of heterogeneity which reflects upon the specialization of their functions in different tissues and locations (Gordon and Taylor, 2005). Macrophage heterogeneity is required to ensure the tissue macrophage has the most effective phenotype to tackle its specific microenvironment, this is particularly important in the gut. Tissue macrophages in the gut isolated from the lamina propria have a unique phenotype characterised by high phagocytic and bactericidal activity but very poor production of pro-inflammatory cytokines which makes them perfectly suited to their microenvironment (Gordon and Taylor, 2005). There are many specialised tissue macrophages that have very distinct functions including; osteoclasts in the bone which breakdown bone deposits for bone remodelling, alveolar macrophages (dust cells) in the lung that break down foreign material and pathogens, and microglia in the brain which play a role in neuronal development homeostasis and the recovery from pathology (Boyce et al, 2008; Rubins, 2003; Prinz et al, 2014). The theory that tissue macrophage populations are replenished from circulating monocytes in the blood is somewhat true but the most diverse tissue macrophages such as microglia, alveolar macrophages and osteoclasts are replenished through self-renewal and proliferation (Yona and Jung, 2009). There is a substantial number of studies discussing whether macrophages originating from monocytes in the blood can differentiate into resident tissue macrophages. In most cases the monocyte subset that the macrophage originated from determines its ability to differentiate into a specialized resident tissue macrophage, this is particularly true in the lung as studies have shown only Ly6Clo, not Ly6Chi, monocytes have the ability to differentiate into enchymal lung macrophages (Landsman et al, 2007). In regards to the more complex and specialised alveolar macrophages in the lung, studies have shown that these macrophage s require a parenchymal lung macrophage intermediate (Landsman and Jung, 2007). Circulating monocytes in the blood were long believed to be the origin of specialised tissue macrophages but recent evidence has shown that this is incorrect and proven that many of these tissue macrophage populations are developed long before birth (Epelman et al, 2014). Origins of Tissue Macrophages Macrophages are first observed during embryonic day 6.5 and are produced in the yolk sac during what is termed as primitive haematopoiesis (Epelman et al, 2014). During this early stage in development macrophages are the only immune cell produced due to restricted progenitors in the yolk sac. During embryonic days 8.5 10.5 hematopoietic stem cells (HSCs) emerge from the aorta-gonad meso-nephros (AGM) and give rise to all immune lineages (Epelman et al, 2014). At embryonic day 10.5 HSCs migrate from the AGM to the foetal liver, the foetal liver then becomes the major hematopoietic organ until birth. Only after birth do bone marrow HSCs become the primary progenitors and produce all immune lineages (Orkin and Zon, 2008). Microglia are the only tissue macrophages that are established in the yolk sac and are self-maintained through-out adulthood, all the other tissue macrophages are established from embryonic day 14.5 to birth and either self-maintained by proliferation or replenished b y HSCs in the bone marrow (Ginhoux et al, 2010; Sheng et al, 2015). The arrival of fat-mapping techniques have enabled researchers to precisely track embryonic macrophage populations into adulthood, giving an insight into the relationship between resident tissue macrophages and circulating blood monocytes (Epelman et al, 2014). As previously discussed, microglia are the only tissue macrophage originating from the yolk sac and arise before embryonic day 8 (Ginhoux et al 2010). Fate mapping analysis was used to determine that the origin of microglia was the primitive myeloid precursors in the yolk sac and also proved that microglia are self-maintained independently of any circulating blood monocytes (Ginhoux et al, 2010). There is also evidence that Langerhans cells originate from the yolk sac but only partially (Sheng et al, 2015). The fate mapping study by Sheng proved that microglia and Langerhans cells were the only tissue macrophages that originate from yolk sac precursors and th at most adult tissue macrophages originate from a second wave of haematopoiesis driven by HSCs. (Sheng et al, 2015). The number recent of publications concerning tissue macrophage origins is staggering and is most likely attributed to the arrival of fate mapping techniques. With the large surge of new studies regarding tissue macrophage origins it is important that a clear understanding is generated but this is not always possible with such a complicated subject. Contrasting Studies into Tissue Macrophage Origins There are a few recent studies concerning tissue macrophage origins which are particularly interesting. Sheng (Sheng et al, 2015) arrived at the conclusion that most tissue macrophages originate from HSCs however there are a few publications which contradict Shengs findings. Perdiguero concluded that yolk sac derived erythro-myeloid progenitors, were origin of almost all tissue macrophages which contrasts greatly with Shengs observations. (Perdiguero et al, 2015). Perdiguero also concluded that microglia were derived from erythro-myeloid progenitors rather than primitive yolk sac progenitors that was observed by Sheng, although both do come from the yolk sac (Perdiguero et al, 2015; Sheng et al, 2015). Perdiguero predicted that almost all other tissue macrophages originated from erythro-myeloid progenitors (Perdiguero et al, 2015; Sheng et al, 2015). A study by Hoeffel aligned well with Perdigueros observations but Hoeffel observed that primitive yolk sac progenitors gave rise to mic roglia rather than erythro-myeloid progenitors that was observed by Perdiguero (Hoeffel et al, 2015; Perdiguero et al, 2015). As well as the difference in the development of microglia, Hoeffel predicted that erythro-myeloid progenitors migrated to the foetal liver, giving rise to foetal monocytes which were then responsible for the production of tissue macrophages. (Hoeffel et al, 2015). Each of these 3 examples also propose a separate proposed major path of ontogeny and differentiation to adult tissue macrophage state. Perdiguero proposes erythro-myeloid progenitors from the yolk sac as the major precursor of tissue macrophages, Heoffel proposes erythro-myeloid progenitors from the foetal liver, as foetal monocytes, as the major precursor and, Sheng proposes that HSCs from the foetal liver are the major precursor (Perdiguero et al, 2015; Hoeffel et al, 2015; Sheng et al, 2015; Guinhoux and Guilliams, 2016). Although the observations made by Sheng are profoundly different to those m ade by Perdiguero and Hoeffel it could be down to the fate mapping technique they used. The model they used is not adapted to distinguish between late erythro-myeloid progenitors and foetal HSCs which has clearly effected the conclusion they have come to (Guinhoux and Guilliams, 2016). Although fate mapping has great potential in advancing our knowledge of cellular ontogeny there are certain limitation that come with it and these limitations must be considered when designing experiments and analysing data (Guinhoux and Guilliams, 2016). Do Tissue Macrophage Origins Matter? Determining the origins of tissue macrophages may be valuable for furthering our knowledge and understanding of their development but do their origins have any influence in determining their function? As well as ontogeny, diversity in the functions of tissue macrophages can also be attributed to the local signals received by the macrophages. These local changes can drive the expression of unique transcription factors which in turn lead to different functions (Lavin et al, 2015). There is a lot of evidence to suggest that the tissue macrophages microenvironment can alter its function, the plasticity of tissue macrophages allows them to adjust their functions to inflammatory events (Lavin et al, 2015). Using ionizing radiation most embryonic-derived tissue macrophages can be eliminated, they can then be replaced with donor-derived bone marrow progenitors to determine if the wild type state of the tissue can be restored. Using this technique, studies have proven that bone marrow progeni tors can completely restore the enhancer profile and transcriptional programme of the embryonic-derived tissue macrophages that were eliminated (Lavin et al, 2015). A very recent study has shown that yolk sac macrophages, foetal liver monocytes and adult bone marrow monocytes can all successfully differentiate into alveolar macrophages in the lung after the removal of the native alveolar macrophages using ionizing radiation (van de Laar et al, 2016). The study also showed that other already developed tissue macrophages, liver, peritoneal and colon macrophages cannot successfully differentiate into alveolar macrophages in the lung. This finding suggests that the plasticity of the mononuclear phagocyte system is at its largest during the precursor stage and after differentiation to tissue-resident macrophages no further phenotypic changes of macrophage types can take place (van de Laar, 2016). Perhaps the most interesting finding from this study is that the alveolar macrophages differ entiated from yolk sac macrophages, foetal liver monocytes and bone marrow monocytes were still able to self-maintain and prevent alveolar proteinosis (van de Laar, 2016). Similar results have also been observed with Kupffer cells. Kupffer cells were eliminated from the liver using diphtheria toxin-mediated depletion allowing its niche to become vacant. Observations showed that circulating monocytes can engraft the liver and adopt the transcriptional profile of the eliminated Kupffer cells and also become long-living self-renewing cells like their eliminated counterparts (Scott et al, 2015). These new findings question whether the origin of tissue macrophages is truly important to their function as the progenitors and monocytes tested have all been able to restore the tissues lost macrophages successfully without any loss of function. Conclusion Although determining the origins of tissue macrophages and other members of the immune system is important for the progression of our knowledge it remains to be seen whether the actual origins have any implications on the function of the tissue macrophages. The techniques used in the publications discussed are still very new and still require refinement, I believe further refinement of the techniques will enable a more detailed and accurate description on the origins of tissue macrophages and the role the origins play in their function. References       BOYCE, B.F., YAO, Z. XING, L. 2009Osteoclasts have multiple roles in bone addition to bone resorption.Critical Reviews in Eukaryotic Gene Expression, 19.3, 171-180 EPELMAN, S., LAVINE, K.J. RANDOLPH, G.J. 2014Origin and functions of tissue macrophages.Immunity, 41.1, 21-35 GINHOUX, F., GRETER, M., LEBOEUF, M., NANDI, S., SEE, P., GOKHAN, S., MEHLER, M.F., CONWAY, S.J., GUAN NG, L., STANLEY, E.R., SAMOKHVALOV, I.M. MERAD, M. 2010Fate mapping analysis reveals that adult microglia derive from primitive macrophages.Science, 330.6005, 841-845 GUINHOUX, F. GUILLIAMS 2016Tissue-resident macrophage ontogeny and homeostasis.Immunity, 44.3, 439-449 GORDON, S. 2007The macrophage: past, present and future.European Journal of Immunology, 37, 9-17 GORDON, S. TAYLOR, P.R. 2005Monocyte and macrophage heterogeneity.Nature Reviews: Immunology, 5.12, 953-964 HASHIMOTO, D., CHOW, A., NOIZAT, C., TEO, P., BEASLEY, M.B., LEBOEUF, M., BECKER, C.D., SEE, P., PRICE, J., LUCAS, D., GRETER, M., MORTHA, A., BOYER, S.W., FORSBERG, E.C., TANAKA, M., VAN ROOIJEN, N., GARCIA-SASTRE, A., STANLEY, E.R., GINHOUX, F., FRENETTE, P.S. MERAD, M. 2013Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.Immunity, 38.4, 792-804 HOEFFEL, G., CHEN, J., LAVIN, Y., LOW, D., ALMEIDA, F.F., SEE, P., BEAUDIN, A.E., LUM, J., LOW, I., FORSBERG, E.C, POIDINGER, M., ZOLEZZI, F., LARBI, A., NG, L.G., CHAN, J.K., GRETER, J.K., BECHER, B., SAMOKHVALOV, I.M., MERAD, M. GINHOUX, F. 2015C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages.Immunity, 42.4, 665-678 LANDSMAN, L., VAROL, C. JUNG, S. 2007Distinct differentiation potential of blood monocyte subsets in the lung. Journal of Immunology, 178.4, 2000-2007 LANDSMAN, L. JUNG, S. 2007Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages.Journal of Immunology, 179.6, 3488-3494 LAVIN, Y., MORTHA, A., RAHMAN, A. MERAD, M. 2016Regulation of macrophage development and function in peripheral tissues.Nature Reviews: Immunology, 15.12, 731-744 ORKIN, S.H. ZON, L.I. 2008Haematopoiesis: an evolving paradigm for stem cell biology.Cell, 132, 631-644 PERDIGUERO, E.G., KLAPPROTH, K., SCHULZ, C., BUSCH, K., AZZONI, E., CROZET, L., GARNER, H., TROUILLET, C., DE BRUIJN, M.F., GEISSMANN, F. RODEWALD, H.R. 2014Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.Nature, 518, 547-551 PRINZ, M., TAY, T.L., WOLF, Y. JUNG, S. 2014Microglia: unique and common features with other tissue macrophages.Acta Neuropathologica, 128.3, 319-331 RUBINS, J.B. 2003Alveolar macrophages: wielding the double-edged sword of inflammation.American Journal of Respiratory and Critical Care Medicine, 167.2, 103-104 SCOTT, C.L., ZHENG, F., DE BAETSELIER, P., MARTENS, L., SAEYS, Y., DE PRIJCK, S., LIPPENS, S., ABELS, C., SCHOONOOGHE, S., RAES, G., DEVOOGDT, N., LAMBRECHT, B.N., BESCHIN, A. GUILLIAMS, M. 2016Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells.Nature Communications, 7, 10321 SHENG, J., RUEDL, C. KARJALAINEN, K. 2015Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells.Immunity, 43.2, 382-393 TAUBER, A.I. 2003Metchnikoff and the phagocytosis theory.Nature Reviews: Molecular Cell Biology, 4, 897-901 VAN DE LAAR, L., SAELENS, W., DE PRIJCK, S., MARTENS, L., SCOTT, C.L., VAN ISTERDAEL, G., HOFFMANN, E., BEYAERT, R., SAEYS, Y., LAMBRECHT, B.N. GUILLIAMS, M. 2016Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages.Immunity, 44.4, 755-768 VAN FURTH, R. COHN, Z.A. 1968The origin and kinetics of mononuclear phagocytes.The Journal of Experimental Medicine, 128.3, 415-435 YONA, S., KIM, K.W., WOLF, Y., MILDNER, A., VAROL, D., BRECKER, M., STRAUSS-AYALI, D., VIUKOV, S., GUILLIAMS, M., MISHARIN, A., HUME, D.A., PERLMAN, H., MALISSEN, B., ZELZER, E. JUNG, S. 2013Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.Immunity, 38.1, 79-91 YONA, S. JUNG, S. 2009Monocytes: subsets, origins, fates, and functions. Current Opinion in Hematology, 17.1, 53-59

Personal Environmental Ethics :: essays research papers

There are some people who believe that the United States' strictly forced endangered species laws seriously hamper our economy. I on the other hand must disagree. The endangered species laws were created for an important reason: to protect our earth's biological diversity. Whenever humanity interferes with the ecosystem for the purpose of economic growth it tears it apart piece by piece. It is for reasons like these we must have such tough laws, as in the Endangered Species Act. The fact of the matter is that a problem still exists today. Many policy-makers and forest industry representatives argue that the current forest and wildlife conditions constitute a "forest health crisis"(Peters, Frost, & Pace, 1999). The current crisis results from companies who tear down forests for their own profit. By doing this not only is the forest itself being destroyed, but the wildlife within it. Furthermore, in 1990 the EPA's scientific research team stated that destruction of habit ats, and species extinction are two of the four most critical global environmental issues (Biodiversity, 1999). As can be seen, companies who destroy the ecosystem for economic gain are creating irreversible problems that future laws cannot correct. To prevent further problems from occurring we must maintain all biodiversity laws. The basis of the laws are to protect all life, including all human life; and are crucial for present and future generations (Biodiversity, 1999). The federal government has taken charge of this situation, most notably through its endangered species protection efforts (Biodiversity, 1999). This has become a controversial, but necessary step in protection our ecosystem and all of the valuable resources it has to offer. Understanding those environmental issues are subjects of disagreement arising from different perspectives and values; the controversy of economic gain verse ecological conservation is not easily settled. I support wildlife preservation only to prevent extinction. I believe without these laws that we as humans will suffer greatly, because we would be unable to reap the benefits of the ecosystem. I agree with the congressional findings that various species of fish, wildlife, and plants have been rendered extinct as a consequence of economic growth and development intemperate by adequate concern and conservation (O'Laughlin, 1998).

Restoring the Balance :: Psychology Psychological Freud Essays

"Restoring the Balance" World War I was a war of new technology. There were machine guns, gas bombs, and trenches. Because of this new technology, World War I was also a war filled with atrocities. The men fighting in the war experienced horrors that no human being should have ever experienced. The novel Regeneration by Pat Barker addresses the question of how these soldiers were supposed to recover from these horrors. For Dr. W.H.R. Rivers, there was only one answer -- psychology. On page 29, a patient of Rivers' named Anderson tells Rivers, "That's what you Freudian Johnnies are on about all the time, isn't it? Nudity, snakes, corsets." Freudian therapy is also alluded to on pages 31 and 46, although Freudian methods of analyzing dreams, recognizing symbols, and understanding the unconscious are constants. Rivers helps to bring the traumatized soldiers back to a reality where they can accept life and the duties that they must fulfill through the use of a psychology which draws upon Freud's theories. The a ppearance of Freudian psychology in Regeneration helps to acknowledge the frailty of the human mind, body, and soul. Rivers' use of psychology is a way to restore the delicate balance of life, giving renewal to a life thought hopeless by its possessor. Sigmund Freud's life work as a psychologist and psychoanalyst has been very influential. Sigmund Freud (1856-1931) attended college in Vienna where he started writing his many treatises and theories on the psychoanalytical approach. In 1881, Freud got his doctor's degree in medicine. From 1885-86, Freud spent time studying the effects of hypnosis and studied hysteria. From 1900 to 1916, Freud wrote many of his most famous works, such as The Interpretation of Dreams, and gave many lectures. Of all his works and theories, Freud is most known for his theories on the unconscious and for the importance he puts on sex (Thornton). With the start of World War I, Freud began studying several patients suffering from hysteria and shell-shock. He died of cancer in England in 1931. Freud studied and wrote several theories on neurosis and the use of psycho-analysis as a form of therapy. Freud said that there were several forms in which neurosis appears, including repression, regression, and fixation. Freud felt that in order "to effect a cure, he must facilitate the patient himself to become conscious of unresolved conflicts buried in the deep recesses of the unconscious mind, and to confront and engage with them directly" (Thornton).